1503, Oct 241539, May 1
a Holy Roman Empress and Queen of Spain, Germany, Italy, Naples and Sicily and Duchess of Burgundy by her marriage to Holy Roman Emperor Charles V, and regent of Spain during the absences of her husband during 1529-1532, 1535-1536 and 1538-1539. Isabella was the granddaughter of the Catholic Monarchs, Isabella I of Castile and Fernando II of Aragon. Throughout her life, many would compare her to her grandmother for her character and her determination in politics.
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03/10/1526-Emperor Charles V marries princess Isabella of Portugal 
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