 | John Cabot | 1450 ca | 1470 | | 1500 | 1500 ca |
| | an Italian navigator and explorer whose 1497 discovery of parts of North America under the commis... |
 | Bartolomeu Dias | 1451 ca | 1480 | | 1500 | 1500, May 29 |
| | a nobleman of the Portuguese royal household, was a Portuguese explorer. He sailed around the sou... |
| Pero de Barcelos | unknown | 1498 | | 1501 | unknown |
| | a Portuguese navigator who explored the coasts of North America with João Fernandes Labrador, h... |
| Joao Fernandes Lavrador | 1453 | 1498 | | 1501 | 1501 ca |
| | a Portuguese explorer of the late 15th century. He was the first modern explorer in the coasts of... |
| Nicolau Coelho | 1460 ca | 1490 | | 1502 | 1502 |
| | an expert Portuguese navigator and explorer during the age of discovery. He participated in the d... |
| Miguel Corte-Real | 1448 | 1502 | | 1502 | unknown |
| | a Portuguese explorer who charted about 600 miles of the coast of Labrador. In 1501, he disappear... |
| Goncalo Coelho | unknown | 1501 | | 1504 | unknown |
| | a Portuguese explorer who belonged to a prominent family in northern Portugal. He commanded two e... |
| Christopher Columbus | 1451, Oct | 1473 | | 1505 | 1506, May 20 |
| | an Italian explorer, navigator, colonizer and citizen of the Republic of Genoa. Under the auspice... |
| Ludovico di Varthema | 1470 ca | 1502 | | 1507 | 1517 |
| | an Italian traveller, diarist and aristocrat known for being the first non-Muslim European to ent... |
| Diogo de Azambuja | 1432 | 1450 | | 1509 | 1518 |
| | a Portuguese noble. He was a knight of the Order of Aviz in the service of the Infante Dom Pedro,... |
 | Jean Cousin | unknown | 1480 | | 1509 | unknown |
| | a 15th-century French Normand navigator who was said to have discovered the New World in 1488, fo... |
| Diogo Dias | unknown | 1490 | | 1509 | unknown |
| | a 15th-century Portuguese explorer. He was the brother of Bartolomeu Dias and discovered some of ... |
| Andre Goncalves [1] | unknown | 1490 | | 1509 | unknown |
| | A Portuguese explorer that accompanied Pedro Álvares Cabral in the discovery of Brazil. Gonçalv... |
 | Alonso de Ojeda | 1465/66/68 | 1490 | | 1509 | 1515 |
| | a ruthless and cunning explorer who first sailed to the New World on Columbus’ second voyage in... |
| Luis Pires | unknown | 1490 | | 1509 | unknown |
| | a Portuguese explorer who accompanied Pedro Álvares Cabral in the discovery of Brazil, being one... |
| Amerigo Vespucci | 1454, Mar 9 | 1497 | | 1509 | 1512, Feb 22 |
| | an Italian explorer, financier, navigator and cartographer who first demonstrated that Brazil and... |
| Lourenco de Almeida | 1480 ca | 1500 | | 1509 | 1508, Mar |
| | a Portuguese explorer and military commander. He was born in Martim, Kingdom of Portugal, the son... |
| Pero de Ataide | 1450 ca | 1500 | | 1509 | 1504, Feb/Mar |
| | a Portuguese sea captain in the Indian Ocean active in the early 1500s. He was briefly captain of... |
| Vasco de Ataide | unknown | 1500 | | 1509 | unknown |
| | a Portuguese sailor whose ship was a part of Pedro Álvares Cabral 1500 expedition to India. His ... |
| Joao da Nova | 1460 ca | 1500 | | 1509 | 1509, Jul |
| | a Galician explorer of the Atlantic and Indian Oceans at the service of Portugal. He is credited ... |
| Sebastian de Ocampo | unknown | 1500 | | 1509 | unknown |
| | a Spanish navigator and explorer. He is believed to have been the first navigator to have circumn... |
| Diogo Fernandes Pereira | unknown | 1500 | | 1509 | unknown |
| | a Portuguese 16th-century navigator, originally from Setúbal, Portugal. Diogo Fernandes was the... |
| Francisco de Almeida | 1450 ca | 1490 | | 1510 | 1510, Mar 1 |
| | a Portuguese nobleman, soldier and explorer. He distinguished himself as a counsellor to King Joh... |
| Pero de Alenquer | 1480 ca | 1500 | | 15109 | 1514 ca
|
| | a 15th-century Portuguese explorer of the African coast. Pêro was born in Alenquer, and accompan... |
| Afonso de Albuquerque | 1453 ca | 1471 | | 1515 | 1515, Dec 16 |
| | a Portuguese general, a "great conqueror," a statesman, and an empire builder. He is generally co... |
| Juan Diaz de Solis | 1470 | 1500 | | 1516 | 1516 |
| | In 1500 and 1508, Diaz de Solis joined Vincente Pinzón on two voyages exploring along the coast ... |
 | Antony Welser | unknown | 1500 | | 1518 | 1518 |
| | One of the first Europeans to use the sea route to India discovered by Vasco de Gama. |
| Diego Velasquez de Cuellar | 1465 | 1490 | | 1519 | 1524, Jun 12 |
| | a Spanish conquistador. He first visited the New World with the crew of Christopher Columbus' sec... |
| Antonio de Abreu | 1480 ca | 1500 | | 1519 | 1514 ca |
| | a 16th-century Portuguese navigator and naval officer. He participated under the command of Afons... |
| Vasco Nunez de Balboa | 1475 ca | 1500 | | 1519 | 1519, Jan 12/21 |
| | a Spanish explorer, governor, and conquistador. He is best known for having crossed the Isthmus o... |
| Binot Paulmier de Gonneville | unknown | 1500 | | 1519 | unknown |
| | French navigator of the early 16th century, was widely believed in 17th and 18th century France t... |
| Duarte Fernandes | unknown | 1500 | | 1519 | unknown |
| | a Portuguese diplomat and the first European to establish diplomatic relations with Thailand, whe... |
| Fernao de Loronha | 1470 ca | 1500 | | 1519 | 1540 ca |
| | a prominent 16th-century Portuguese merchant of Lisbon He was the first charter-holder (1502–15... |
| Ferdinand Magellan | 1480 | 1495 | | 1521 | 1521 |
| | a Portuguese explorer who organised the Spanish expedition to the East Indies from 1519 to 1522, ... |
| Duarte Barbosa | 1480 ca | 1500 | | 1521 | 1521, May 1 |
| | a Portuguese writer and Portuguese India officer between 1500 and 1516–1517, with the post of s... |
| Vasco da Gama | 1460s | 1480 | | 1524 | 1524, Dec 24 |
| | a Portuguese explorer. He was the first European to reach India by sea, linking Europe and Asia f... |
| Goncalo Alvares | unknown | 1490 | | 1524 | 1524 |
| | a Portuguese explorer who actively participated in the age of discovery starting from the second ... |
| Giovanni da Verrazzano | 1485 | 1508 | | 1528 | 1528 |
| | an Italian explorer of North America, in the service of King Francis I of France. He is renowned ... |
| Cristovao Jacques | 1480 ca | 1500 | | 1529 | 1530+ |
| | a Portuguese noble of Aragonese descent. In 1516, in command of two caravels, he was in charge of... |
| Hernan Cortes | 1485 | 1504 | | 1547 | 1547, Dec 2 |
| | a Spanish Conquistador who led an expedition that caused the fall of the Aztec Empire and brought... |
| Sebastian de Belalcazar | 1479/80/95 | 1507 | | 1551 | 1551 |
| | a Spanish conquistador. He entered Nicaragua with Francisco Hernández de Córdoba in 1524 during... |
 | Piri Reis | 1467 ca | 1481 | | 1553 | 1553 |
| | an Ottoman admiral, geographer, and cartographer. Piri began engaging in government-supported pri... |
| Sebastian Cabot | 1474 ca | 1494 | | 1557 | 1557, Dec |
| | an Italian explorer, likely born in the Venetian Republic. He was the son of Italian explorer Joh... |
| Diogo Rodrigues | 1495 ca | 1507 | | 1577 | 1577, Apr 21 |
| | a Portuguese explorer of the Indian Ocean who sailed as an ordinary helmsman under the command of... |
| Pero Escobar | unknown | 1470 | | 159 | unknown |
| | a 15th-century Portuguese navigator who discovered São Tomé, Annobon, and Príncipe islands, to... |
| Gaspar de Lemos | unknown | 1500 | | 162 | unknown |
| | a Portuguese explorer and captain of the supply ship of Pedro Álvares Cabral's fleet that discov... |
