Duke of Ferrara during the time of the War of the League of Cambrai. In the first year of his rule he uncovered a plot by his brother Ferrante and half-brother Giulio d'Este, directed against him and his other brother Ippolito. In September 1506 a trial for lèse majesté and high treason was held and, as expected, the death sentence was passed, but just as Ferrante and Giulio were about to mount the gallows they were informed that the duke had commuted their sentence to life imprisonment.
