 | Afonso de Albuquerque | 1453 ca | 1471 | | 1515 | 1515, Dec 16 |
| | a Portuguese general, a "great conqueror," a statesman, and an empire builder. He is generally co... |
| Juan Diaz de Solis | 1470 | 1500 | | 1516 | 1516 |
| | In 1500 and 1508, Diaz de Solis joined Vincente Pinzón on two voyages exploring along the coast ... |
 | Antony Welser | unknown | 1500 | | 1518 | 1518 |
| | One of the first Europeans to use the sea route to India discovered by Vasco de Gama. |
 | Diego Velasquez de Cuellar | 1465 | 1490 | | 1519 | 1524, Jun 12 |
| | a Spanish conquistador. He first visited the New World with the crew of Christopher Columbus' sec... |
| Antonio de Abreu | 1480 ca | 1500 | | 1519 | 1514 ca |
| | a 16th-century Portuguese navigator and naval officer. He participated under the command of Afons... |
| Vasco Nunez de Balboa | 1475 ca | 1500 | | 1519 | 1519, Jan 12/21 |
| | a Spanish explorer, governor, and conquistador. He is best known for having crossed the Isthmus o... |
 | Binot Paulmier de Gonneville | unknown | 1500 | | 1519 | unknown |
| | French navigator of the early 16th century, was widely believed in 17th and 18th century France t... |
| Duarte Fernandes | unknown | 1500 | | 1519 | unknown |
| | a Portuguese diplomat and the first European to establish diplomatic relations with Thailand, whe... |
| Fernao de Loronha | 1470 ca | 1500 | | 1519 | 1540 ca |
| | a prominent 16th-century Portuguese merchant of Lisbon He was the first charter-holder (1502–15... |
| Francisco del Puerto | unknown | 1510 | | 1519 | unknown |
| | a cabin boy of the expedition of Juan Díaz de Solís to the Río de la Plata. His last name seem... |
| Ferdinand Magellan | 1480 | 1495 | | 1521 | 1521 |
| | a Portuguese explorer who organised the Spanish expedition to the East Indies from 1519 to 1522, ... |
| Duarte Barbosa | 1480 ca | 1500 | | 1521 | 1521, May 1 |
| | a Portuguese writer and Portuguese India officer between 1500 and 1516–1517, with the post of s... |
| Jorge Alvares | unknown | 1510 | | 1521 | 1521, Jul 8 |
| | credited as the first European explorer to have reached China and Hong Kong by sea. Álvares made... |
| Francisco Serrao | unknown | 1511 | | 1521 | 1521 |
| | a Portuguese explorer and a cousin of Ferdinand Magellan. His 1512 voyage was the first known Eur... |
| Vasco da Gama | 1460s | 1480 | | 1524 | 1524, Dec 24 |
| | a Portuguese explorer. He was the first European to reach India by sea, linking Europe and Asia f... |
| Goncalo Alvares | unknown | 1490 | | 1524 | 1524 |
| | a Portuguese explorer who actively participated in the age of discovery starting from the second ... |
| Gomes de Sequeira | unknown | 1525 | | 1525 | unknown |
| | a Portuguese explorer in the early 16th century. It has been suggested by some historians that Go... |
| Juan Sebastian Elcano | 1476 | 1509 | | 1526 | 1526, Aug 4 |
| | a Basque explorer who completed the first circumnavigation of the Earth. After Ferdinand Magellan... |
| Garcia Jofre de Loaisa | 1490 | 1525 | | 1526 | 1526, Jul 20 |
| | Commanded a 16th-century voyage of discovery to the Pacific Ocean and ordered by King Charles I ... |
 | Giovanni da Verrazzano | 1485 | 1508 | | 1528 | 1528 |
| | an Italian explorer of North America, in the service of King Francis I of France. He is renowned ... |
| Cristovao Jacques | 1480 ca | 1500 | | 1529 | 1530+ |
| | a Portuguese noble of Aragonese descent. In 1516, in command of two caravels, he was in charge of... |
| Panfilo de Narvaez | 1470 | 1510 | | 1529 | 1528 |
| | Explorer |
| Alonso de Salazar | unknown | 1520 | | 1529 | 1526, Sep 5 |
| | the Spaniard, born in Las Encartaciones who discovered the Marshall Islands on August 21, 1526. D... |
| Alvaro de Saavedra Ceron | unknown | 1526 | | 1529 | unknown |
| | one of the Spanish explorers in the Pacific Ocean. It is unknown the exact date and place of his ... |
| Gonzalo Guerrero | unknown | 1510 | | 1530 | 1530 ca |
| | a sailor from Palos, in Spain who shipwrecked along the Yucatán Peninsula and was taken as a sl... |
| Diego de Almagro | 1475 ca | 1510 | | 1538 | 1538, Jul 8 |
| | a Spanish conquistador and a companion and later rival of Francisco Pizarro. He participated in t... |
| Hernan Ponce de Leon | unknown | 1510 | | 1539 | unknown |
| | a Spanish conquistador who participated in the discovery of Panama, Costa Rica, and Nicaragua in ... |
| Francisco Alvares | 1465 | 1515 | | 1539 | 1536~1541 |
| | a Portuguese missionary and explorer. In 1515 he traveled to Ethiopia as part of the Portuguese e... |
| Pedro de Alvarado | 1485 ca | 1510 | | 1541 | 1541, Jul 4 |
| | a Spanish conquistador and governor of Guatemala. He participated in the conquest of Cuba, in Jua... |
| Francisco de Orellana | 1490/1511 | 1540 | | 1542 | 1546, Nov |
| | a Spanish explorer and conquistador. He completed the first known navigation of the entire length... |
| Jacques Cartier | 1491, Dec 31 | 1534 | | 1543 | 1557, Sep 1 |
| | a French explorer of Breton origin who claimed what is now Canada for France. Jacques Cartier was... |
| Ruy López de Villalobos | 1500 ca | 1520 | | 1544 | 1544, Apr 4 |
| | a Spanish explorer who sailed the Pacific from Mexico to establish a permanent foothold for Spain... |
| Martim Afonso de Sousa | 1500 ca | 1530 | | 1545 | 1571, Jul 21 |
| | a Portuguese fidalgo, explorer and colonial administrator. Born in Vila Viçosa, he was commander... |
| Bartholomeus Welser VI | 1512, Oct 26 | 1540 | | 1546 | 1546, May |
| | the son of Bartholomeus V. Welser (the elder), he journeyed to Venezuela to join an expedition by... |
| Hernan Cortes | 1485 | 1504 | | 1547 | 1547, Dec 2 |
| | a Spanish Conquistador who led an expedition that caused the fall of the Aztec Empire and brought... |
| Inigo Ortiz de Retes | 1505 ca | 1538 | | 1548 | unknown |
| | a 16th-century Spanish maritime explorer, who navigated the northern coastline of the Pacific–M... |
| Francisco Xerez | 1495 | 1514 | | 1549 | 1565 ca |
| | a Spanish explorer-turned-historian, the personal secretary of conquistador Francisco Pizarro. He... |
| Alvar Nunez Cabeza de Vaca | 1490 ca | 1520 | | 1549 | 1557 ca |
| | a Spanish explorer of the New World, and one of four survivors of the 1527 Narváez expedition. D... |
 | James Alday | 1516 | 1540 | | 1549 | 1576 ca |
| | a 16th-century English navigator, explorer and privateer. He participated in raids against the Sp... |
| Lourenço Marques | unknown | 1540 | | 1549 | unknown |
| | a 16th-century Portuguese trader and explorer. Marques explored the area that is now Maputo Bay i... |
| Sebastian de Belalcazar | 1479/80/95 | 1507 | | 1551 | 1551 |
| | a Spanish conquistador. He entered Nicaragua with Francisco Hernández de Córdoba in 1524 during... |
| Fernao Pires de Andrade | unknown | 1510 | | 1552 | 1552 |
| | a Portuguese merchant, pharmacist, and official diplomat under the explorer and Portuguese Malacc... |
| Francis Xavier | 1506, Apr 7 | 1534 | | 1552 | 1552, Dec 3 |
| | a Navarrese Roman Catholic missionary, born in Javier (Xavier in Navarro-Aragonese), Kingdom of N... |
 | Piri Reis | 1467 ca | 1481 | | 1553 | 1553 |
| | an Ottoman admiral, geographer, and cartographer. Piri began engaging in government-supported pri... |
| Pedro de Valdivia | 1497, Apr 17 | 1520 | | 1553 | 1553, Dec 25 |
| | a Spanish conquistador and the first royal governor of Chile. After serving with the Spanish army... |
| Hans Staden | 1525 ca | 1547 | | 1555 | 1579 ca |
| | a German soldier and explorer who voyaged to South America in the middle of the sixteenth century... |
| Domingo Martinez de Irala | 1509 ca | 1530 | | 1556 | 1556 ca |
| | a Spanish Basque conquistador. He headed for the Americas in 1535 enrolled in the expedition of P... |
| Sebastian Cabot | 1474 ca | 1494 | | 1557 | 1557, Dec |
| | an Italian explorer, likely born in the Venetian Republic. He was the son of Italian explorer Joh... |
| Hernando de Alarcon | unknown | 1540 | | 1559 | unknown |
| | a Spanish navigator of the 16th century, noted for having led an early expedition to the Baja Cal... |
| Lope de Aguirre | 1510 ca | 1530 | | 1561 | 1561, Oct 27 |
| | a Basque Spanish conquistador in South America. Nicknamed El Loco ('the Madman'), he styled himse... |
| Miguel Lopez de Legazpi | 1502 ca | 1528 | | 1565 | 1572, Aug 20 |
| | a Basque Spanish navigator and governor who established the first Spanish settlement in the East ... |
| Gonzalo Jimenez de Quesado | 1506/09 | 1535 | | 1573 | 1579, Feb 16 |
| | a Spanish explorer and conquistador in Colombia. He explored the northern part of South America. ... |
| Diogo Rodrigues | 1495 ca | 1507 | | 1577 | 1577, Apr 21 |
| | a Portuguese explorer of the Indian Ocean who sailed as an ordinary helmsman under the command of... |
| Juan Perez de Zurita | 1516 | 1536 | | 1579 | 1595 ca |
| | a Spanish Conquistador. In 1536 he began his military career. In 1548 he was in Granada and in 15... |
| Pero Escobar | unknown | 1470 | | 159 | unknown |
| | a 15th-century Portuguese navigator who discovered São Tomé, Annobon, and Príncipe islands, to... |
| Gaspar de Lemos | unknown | 1500 | | 162 | unknown |
| | a Portuguese explorer and captain of the supply ship of Pedro Álvares Cabral's fleet that discov... |
| Andres de Urdaneta | 1498, Nov 30 | 1520 | | 165 | 1568, Jun 3 |
| | a Basque circumnavigator, explorer and Augustinian friar. As a navigator he achieved the "second"... |
| Anthony Jenkinson | 1529 | 1550 | | 166 | 1610/1611 |
| | one of the first Britons to explore Muscovy and present day Russia. Jenkinson was a traveller and... |
